Are HLA-G polymorphisms associated to recurrent pregnancy loss?
نویسندگان
چکیده
منابع مشابه
HLA-G polymorphisms and soluble HLA-G protein levels in women with recurrent pregnancy loss from Basrah province in Iraq.
HLA-G is a nonclassical, class I major histocompatibility complex (MHC) gene that exhibits immunomodulatory properties and likely plays a role in the maintenance of successful pregnancy. In this study, we investigated the role of HLA-G polymorphisms on risk for recurrent pregnancy loss (RPL) and on circulating levels of soluble (s)HLA-G in Iraqi women. DNA and plasma were obtained from blood sa...
متن کاملHaplotype Effect of Two Human Leukocyte Antigen-G Polymorphisms of rs1736933 and rs2735022 on the Recurrent Pregnancy Loss
Background: Recurrent Pregnancy Loss (RPL) is a multifactorial disease that affects 1-3% of couples. Since Human Leukocyte Antigen-G (HLA-G) gene is involved in fetal maternal immune tolerance, mutations in the HLA-G gene can affect the success rate of pregnancy. Objective: The present study aims to investigate the haplotype effect of rs1736933 and rs2735022 polymorphisms found in the HLA-G ge...
متن کاملO-7: Y Chromosome Microdeletions Are Not Associated with Spontaneous Recurrent Pregnancy Loss in A Sinhalese Population in Sri Lanka
Background: Many advances have been made in reproductive medicine yet the spontaneous loss of a pregnancy remains the most common complication of pregnancy. The aetiology of spontaneous recurrent pregnancy loss (RPL) is multifactorial. Y chromosome microdeletions are found in approximately 7% of men with low sperm counts and, compared to the general population, a higher frequency of spontaneous...
متن کاملThe Effect of HLA-DRB1 Sharing between the Couples with Recurrent Pregnancy Loss on the Pregnancy Outcome after Leukocyte Therapy
Background: Miscarriage is a common phenomenon complicating more than half of pregnancies. Recurrent Pregnancy Loss (RPL) is defined as three or more pregnancies lost before the twentieth week of gestation. It is believed that abnormality in maternal immune reaction to fetus and sharing of HLA antigens might be associated with RPL. Objective: To investigate the effect of HLA-DRB1 sharing betwee...
متن کاملP-193: The Association of Apolipoprotien E Polymorphisms with Recurrent Pregnancy Loss
Background: The role of apolipoprotien E polymorphisms do not diagnostic correctly in recurrent pregnancy loss etiology but Apo E has been shown to play an important role in lipid metabolism in pregnancy. We evaluated these polymorphisms in Iranian women with unexplained recurrent pregnancy loss. Materials and Methods: 5 ml Blood were sampling from 81 women with a history of two or more consecu...
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ژورنال
عنوان ژورنال: Italian Journal of Gynaecology and Obstetrics
سال: 2021
ISSN: 2385-0868
DOI: 10.36129/jog.33.01.03